The Man in the High Castle was great, and I am looking forward to the 2nd season. I also watched the first season of The Expanse, which was new to me as I have not read any of the books. So it felt very slow in the beginning, but it got much better by the end.
The Lost Room which you mentioned above was neat, but a pity that it ended as a mini series. The same guy(s) also made a more recent pilot episode (presented as a movie). This would be "Parallels". Since it's a pilot, there was several things that irked me, such as certain actors which I would've replaced, and some lines / script. Other than that, it looked really cool, with a lot of potential. But of course it never got made, so... Even if it's incomplete, I recommend watching it.
My all-time favorite sci-fi series are Star Trek: The Next Generation, Star Trek: Deep Space Nine, and Star Trek: Voyager. For 'reasons' I did not want to watch Star Trek: Enterprise. And I am not on board with the new Star Trek movies at all. They are utter garbage. With news of a new Star Trek series coming up in 2017, I can only hope that it follows the established timeline, somewhere post-VOY/Nemesis, and continues the true philosophy of what Star Trek really is about, instead of becoming a sub par action-based show.
Other than that, X Files, although perhaps not strictly sci-fi, is a classic. And Fringe likewise really fun.